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Acute markers of neutrophilic lung infiltration in the nonhuman primate LPS model
The nonhuman primate LPS model bridges the translation between preclinical rodent and LPS proof of concept studies in healthy volunteers. The response to LPS in the primate is documented at 24h and beyond but less data is available at earlier time points generally utilised in endotoxin exposure studies in man. The aim of this study was to determine whether the temporal inflammatory response at 6 and 24h following LPS exposure in the cynomolgus monkey was similar to man and that observed in rodent studies. The study also evaluated the efficacy of an oral glucocorticoid against measures of pulmonary inflammation. Four cynomolgus monkeys (Macaca fascicularis) were used in a cross-over study design to evaluate the effects of inhalation exposure of LPS on the airway recruitment of inflammatory cells and biomarker production. The close genetic homology of the primate may offer an advantage in the translation of efficacy between preclinical and clinical studies, especially when the same challenge is employed in both.
