Antimicrobial Development

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Characterization of functional impact and disease biomarker responses under one roof

Experienced in vitro microbiology and in vivo teams

Bespoke validation to meet sponsor requirements and deadlines

Access comprehensive services for antimicrobial development, including a wide range of validated in vivo models complimented by full in vitro support. Have a custom need? We are happy to collaborate to develop and validate bespoke models tailored to your criteria. We also offer stand-alone in vitro assays to investigate efficacy against a wide range of bacterial and fungal pathogens. With expertise in efficacy models, pharmacokinetic (PK) models, and safety models, you can count on quality studies with accelerated data delivery. 

In vivo models of infection:

  • Aspergillus lung infection, mouse
  • Candida Albicans sepsis, mouse
  • Hepatitis B virus (HBV), mouse
    •  AAV-HBV, HBV/HDV, HBV mutant
    • HBV infected human liver chimeric mouse model (PXB® mice)
  • Influenza (H1N1), mouse/ferret
  • Methicillin-resistant Staphylococcus aureus (MRSA) Neutropenic thigh infection PK/PD model, rat
  • Pseudomonas aeruginosa lung infection, mouse
  • Respiratory syncytial virus (RSV) lung infection, mouse
  • Streptococcus pneumoniae lung infection, mouse
  • Streptococcus pneumoniae sepsis model, mouse

In vivo study support services:

  • Preparation of bacterial/viral/fungal infective doses, including agar bead prep for bacterial and fungal respiratory models
  • Organ/tissue bioburden counts
    • Viral titre assays (CPE assay, Plaque assay)
    • Bacteriophage plaque assays

In vitro antimicrobial efficacy:

  • In vitro Minimum Inhibitory Concentration (MIC) assays
    • Aerobic/anaerobic bacteria and fungal pathogens (Hazard class 2)
    • Antibiotic resistance/susceptibility testing

Non-animal model for assessment of acute toxicity and antimicrobial efficacy:

  • Galleria mellonella wax moth larva model  - TruLarvTM

Ready to schedule your next study?

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