Electron Microscopy

Transmission Electron Microscopy (TEM)

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Conventional histopathology uses light microscopy to evaluate stained tissue sections on glass slides, however, some objects are too small to distinguish by light microscopy. 

Electron microscopy (EM) is a technique used in biomedical research for obtaining high resolution images to investigate ultrastructural details.

GLP TEM Lab Features

  • In-house automated processors and grid stainers capable of high throughput epoxy resin processing and staining
  • Resin-embedded sections cut using modern ultramicrotomes
  • Toluidine blue staining performed for selection of specific structures for analysis by EM, or for neurotoxicity analysis when electron microscopy may not be needed
  • High quality Transmission Electron Microscopy (TEM) images for review by in house expert TEM pathologists or electronically transferred for client analysis
  • Good Laboratory Practices (GLP) compliant end-to-end; image capture software has been validated to ensure electronic data regulatory compliance. 

When to Include TEM Work

  • Regulatory advice received e.g. the FDA has alerted to expect changes, such as in the mitochondria, and proactive analysis may speed up the IND process
  • Cationic amphiphilic drug with known history and reason to suspect phospholipidosis
  • Biologics—suspect immune complex deposition e.g. kidney glomeruli
  • Observed abnormal cellular presentation (lesion) e.g. vacuoles, or myelin figures in the neurons of brain tissue
Kidney, Cortex - Proximal Tubule

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